Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway

A number of enzymes become functional by binding to zinc during their journey through the early secretory pathway. The zinc transporters (ZnTs) located there play important roles in this step. We have previously shown that two zinc transport complexes, ZnT5/ZnT6 heterodimers and ZnT7 homo-oligomers,...

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Detalhes bibliográficos
Main Authors: Fukunaka, Ayako, Kurokawa, Yayoi, Teranishi, Fumie, Sekler, Israel, Oda, Kimimitsu, Ackland, M. Leigh, Faundez, Victor, Hiromura, Makoto, Masuda, Seiji, Nagao, Masaya, Enomoto, Shuichi, Kambe, Taiho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091242/
https://ncbi.nlm.nih.gov/pubmed/21402707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227173
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