The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation

Secretory and membrane-bound zinc-requiring enzymes are thought to be activated by binding zinc in the early secretory pathway. One such enzyme, tissue-non-specific alkaline phosphatase (TNAP), is activated through a two-step mechanism, via protein stabilization and subsequent enzyme activation thro...

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Veröffentlicht in:Biochem J
Hauptverfasser: Fujimoto, Shigeyuki, Tsuji, Tokuji, Fujiwara, Takashi, Takeda, Taka-aki, Merriman, Chengfeng, Fukunaka, Ayako, Nishito, Yukina, Fu, Dax, Hoch, Eitan, Sekler, Israel, Fukue, Kazuhisa, Miyamae, Yusaku, Masuda, Seiji, Nagao, Masaya, Kambe, Taiho
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557410/
https://ncbi.nlm.nih.gov/pubmed/27303047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160324
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