Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway

A number of enzymes become functional by binding to zinc during their journey through the early secretory pathway. The zinc transporters (ZnTs) located there play important roles in this step. We have previously shown that two zinc transport complexes, ZnT5/ZnT6 heterodimers and ZnT7 homo-oligomers,...

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Hlavní autoři: Fukunaka, Ayako, Kurokawa, Yayoi, Teranishi, Fumie, Sekler, Israel, Oda, Kimimitsu, Ackland, M. Leigh, Faundez, Victor, Hiromura, Makoto, Masuda, Seiji, Nagao, Masaya, Enomoto, Shuichi, Kambe, Taiho
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091242/
https://ncbi.nlm.nih.gov/pubmed/21402707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227173
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