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A nanomolar potency small molecule inhibitor of Regulator of G protein Signaling (RGS) proteins

Regulators of G-Protein signaling (RGS) proteins are potent negative modulators of signal transduction through G-Protein coupled receptors. They function by binding to activated (GTP-bound) Gα subunits and accelerating the rate of GTP hydrolysis. Modulation of RGS activity by small molecules is an a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Blazer, Levi L, Zhang, Haoming, Casey, Emma M, Husbands, Stephen M, Neubig, Richard R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090679/
https://ncbi.nlm.nih.gov/pubmed/21329361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1019622
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