Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

[Image: see text] We herein report the design and synthesis of the first nanomolar binding inhibitor of STAT5 protein. Lead compound 13a, possessing a phosphotyrosyl-mimicking salicylic acid group, potently and selectively binds to STAT5 over STAT3, inhibits STAT5–SH2 domain complexation events in v...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cumaraswamy, Abbarna A., Lewis, Andrew M., Geletu, Mulu, Todic, Aleksandra, Diaz, Diego B., Cheng, Xin Ran, Brown, Carla E., Laister, Rob C., Muench, David, Kerman, Kagan, Grimes, H. Leighton, Minden, Mark D., Gunning, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234445/
https://ncbi.nlm.nih.gov/pubmed/25419444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500165r
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados