Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

[Image: see text] We herein report the design and synthesis of the first nanomolar binding inhibitor of STAT5 protein. Lead compound 13a, possessing a phosphotyrosyl-mimicking salicylic acid group, potently and selectively binds to STAT5 over STAT3, inhibits STAT5–SH2 domain complexation events in v...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Cumaraswamy, Abbarna A., Lewis, Andrew M., Geletu, Mulu, Todic, Aleksandra, Diaz, Diego B., Cheng, Xin Ran, Brown, Carla E., Laister, Rob C., Muench, David, Kerman, Kagan, Grimes, H. Leighton, Minden, Mark D., Gunning, Patrick T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234445/
https://ncbi.nlm.nih.gov/pubmed/25419444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500165r
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