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Differential Protein Dynamics of Regulators of G-protein Signaling: Role in Specificity of Small-molecule Inhibitors
Small-molecule inhibitor selectivity may be influenced by variation in dynamics among members of a protein family. Regulator of G-protein Signaling (RGS) proteins are a family that plays a key role in G-Protein Coupled Receptor (GPCR) signaling by binding to active Gα subunits and accelerating GTP h...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6309336/ https://ncbi.nlm.nih.gov/pubmed/29460621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13778 |
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