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Differential Protein Dynamics of Regulators of G-protein Signaling: Role in Specificity of Small-molecule Inhibitors

Small-molecule inhibitor selectivity may be influenced by variation in dynamics among members of a protein family. Regulator of G-protein Signaling (RGS) proteins are a family that plays a key role in G-Protein Coupled Receptor (GPCR) signaling by binding to active Gα subunits and accelerating GTP h...

詳細記述

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書誌詳細
出版年:J Am Chem Soc
主要な著者: Shaw, Vincent S., Mohammadiarani, Hossein, Vashisth, Harish, Neubig, Richard R.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309336/
https://ncbi.nlm.nih.gov/pubmed/29460621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13778
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