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Conformational Dynamics of a Regulator of G-protein Signaling Protein Reveals a Mechanism of Allosteric Inhibition by a Small Molecule
Regulators of G protein signaling (RGS) proteins are key players in regulating signaling via G protein-coupled receptors. RGS proteins directly bind to the G(α)-subunits of activated heterotrimeric G-proteins, and accelerate the rate of GTP hydrolysis, thereby rapidly deactivating G-proteins. Using...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876963/ https://ncbi.nlm.nih.gov/pubmed/24093330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400568g |
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