Conformational Dynamics of a Regulator of G-protein Signaling Protein Reveals a Mechanism of Allosteric Inhibition by a Small Molecule

Regulators of G protein signaling (RGS) proteins are key players in regulating signaling via G protein-coupled receptors. RGS proteins directly bind to the G(α)-subunits of activated heterotrimeric G-proteins, and accelerate the rate of GTP hydrolysis, thereby rapidly deactivating G-proteins. Using...

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Hlavní autoři: Vashisth, Harish, Storaska, Andrew J., Neubig, Richard R., Brooks, Charles L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876963/
https://ncbi.nlm.nih.gov/pubmed/24093330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400568g
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