Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

Regulators of G protein signaling (RGS) proteins are potent negative modulators of G protein signaling and have been proposed as potential targets for small-molecule inhibitor development. We report a high-throughput time-resolved fluorescence resonance energy transfer screen to identify inhibitors...

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Detalhes bibliográficos
Main Authors: Blazer, Levi L., Roman, David L., Chung, Alfred, Larsen, Martha J., Greedy, Benjamin M., Husbands, Stephen M., Neubig, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939488/
https://ncbi.nlm.nih.gov/pubmed/20571077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065128
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