Spinal Protein Kinase M ζ Underlies the Maintenance Mechanism of Persistent Nociceptive Sensitization

Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized that the persistence of a sensitized state in the spinal dorsal horn might depend on the activity of protein kinase M ζ (PKMζ), an essential mechanism of late long-term potentiation (LTP). To test this...

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Hlavní autoři: Asiedu, Marina N., Tillu, Dipti V., Melemedjian, Ohannes K., Shy, Adia, Sanoja, Raul, Bodell, Bryce, Ghosh, Sourav, Porreca, Frank, Price, Theodore J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090264/
https://ncbi.nlm.nih.gov/pubmed/21543593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6286-10.2011
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