Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment

BACKGROUND: Peripheral nerve injury (PNI) results in a fundamental reorganization of the translational machinery in the injured peripheral nerve such that protein synthesis is increased in a manner linked to enhanced mTOR and ERK activity. We have shown that metformin treatment, which activates aden...

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Bibliografiske detaljer
Main Authors: Melemedjian, Ohannes K, Yassine, Hussein N, Shy, Adia, Price, Theodore J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623807/
https://ncbi.nlm.nih.gov/pubmed/23531341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-14
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