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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

Complement research experienced a renaissance with the discovery of a third activation route, the lectin pathway. We developed a unique model of total lectin pathway deficiency, a mouse strain lacking mannan-binding lectin-associated serine protease-2 (MASP-2), and analyzed the role of MASP-2 in two...

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Autori principali: Schwaeble, Wilhelm J., Lynch, Nicholas J., Clark, James E., Marber, Michael, Samani, Nilesh J., Ali, Youssif Mohammed, Dudler, Thomas, Parent, Brian, Lhotta, Karl, Wallis, Russell, Farrar, Conrad A., Sacks, Steven, Lee, Haekyung, Zhang, Ming, Iwaki, Daisuke, Takahashi, Minoru, Fujita, Teizo, Tedford, Clark E., Stover, Cordula M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088599/
https://ncbi.nlm.nih.gov/pubmed/21502512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101748108
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