Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1

BACKGROUND: Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contribu...

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Publicat a:J Neuroinflammation
Autors principals: Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, Cummings, W. Jason, Takahashi, Minoru, Fujita, Teizo, Demopulos, Gregory, De Simoni, Maria-Grazia, Schwaeble, Wilhelm
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006610/
https://ncbi.nlm.nih.gov/pubmed/27577570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0684-6
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