Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation

The lectin pathway of complement is activated by complexes comprising a recognition component (mannose-binding lectin, serum ficolins, collectin-LK or collectin-K1) and a serine protease (MASP-1 or MASP-2). MASP-1 activates MASP-2, and MASP-2 cleaves C4 and C4b-bound C2. To clarify activation, new c...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Nan, Ruodan, Furze, Christopher M., Wright, David W., Gor, Jayesh, Wallis, Russell, Perkins, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300068/
https://ncbi.nlm.nih.gov/pubmed/28111019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.12.014
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