Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot

The lectin pathway of complement is activated upon binding of mannan-binding lectin (MBL) or ficolins (FCNs) to their targets. Upon recognition of targets, the MBL-and FCN-associated serine proteases (MASPs) are activated, allowing them to generate the C3 convertase C4b2a. Recent findings indicate t...

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Bibliographic Details
Main Authors: Gulla, Krishana C, Gupta, Kshitij, Krarup, Anders, Gal, Peter, Schwaeble, Wilhelm J, Sim, Robert B, O’Connor, C David, Hajela, Krishnan
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842495/
https://ncbi.nlm.nih.gov/pubmed/20002787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03200.x
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