Conformational and Structural Features of HIV-1 gp120 Underlying Dual Receptor Antagonism by the Cross-Reactive Neutralizing Antibody, m18

We investigated the interaction between the cross-reactive HIV-1 neutralizing human monoclonal antibody m18 with HIV-1(YU-2) gp120 in order to understand how this antibody inhibits viral entry into cells. M18 binds to gp120 with high affinity (K(D) ≈ 5 nM) as measured by surface plasmon resonance (S...

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Autors principals: Gift, Syna Kuriakose, Zentner, Isaac J., Schön, Arne, McFadden, Karyn, Umashankara, M., Rajagopal, Srivats, Contarino, Mark, Duffy, Caitlin, Courter, Joel R., Zhang, Mei-Yun, Gershoni, Jonathan M., Cocklin, Simon, Dimitrov, Dimiter S., Smith, Amos B., Freire, Ernesto, Chaiken, Irwin M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088361/
https://ncbi.nlm.nih.gov/pubmed/21351734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101160r
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