CMX001 (1-O-Hexadecyloxypropyl-Cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-Derived Astrocytes

Polyomavirus JC (JCV) replication causes progressive multifocal leukoencephalopathy (PML), a frequently fatal brain disease in immunodeficient patients, yet antiviral drugs are lacking. We characterized the lipid conjugate 1-O-hexadecyloxypropyl-cidofovir (CMX001) regarding JCV (Mad-4) replication i...

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Bibliographic Details
Main Authors: Gosert, Rainer, Rinaldo, Christine Hanssen, Wernli, Marion, Major, Eugene O., Hirsch, Hans H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088264/
https://ncbi.nlm.nih.gov/pubmed/21402853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00046-11
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