Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

A journey back in time is possible at the molecular level by reconstructing proteins from extinct organisms. Here we report the reconstruction, based on sequence predicted by phylogenetic analysis, of seven Precambrian thioredoxin enzymes (Trx), dating back between ~1.4 and ~4 billion years (Gyr). T...

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Autori principali: Perez-Jimenez, Raul, Inglés-Prieto, Alvaro, Zhao, Zi-Ming, Sanchez-Romero, Inmaculada, Alegre-Cebollada, Jorge, Kosuri, Pallav, Garcia-Manyes, Sergi, Kappock, T. Joseph, Tanokura, Masaru, Holmgren, Arne, Sanchez-Ruiz, Jose M., Gaucher, Eric A., Fernandez, Julio M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087858/
https://ncbi.nlm.nih.gov/pubmed/21460845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2020
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