Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

A journey back in time is possible at the molecular level by reconstructing proteins from extinct organisms. Here we report the reconstruction, based on sequence predicted by phylogenetic analysis, of seven Precambrian thioredoxin enzymes (Trx), dating back between ~1.4 and ~4 billion years (Gyr). T...

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Main Authors: Perez-Jimenez, Raul, Inglés-Prieto, Alvaro, Zhao, Zi-Ming, Sanchez-Romero, Inmaculada, Alegre-Cebollada, Jorge, Kosuri, Pallav, Garcia-Manyes, Sergi, Kappock, T. Joseph, Tanokura, Masaru, Holmgren, Arne, Sanchez-Ruiz, Jose M., Gaucher, Eric A., Fernandez, Julio M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087858/
https://ncbi.nlm.nih.gov/pubmed/21460845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2020
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