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Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching
Mdm2 (Murine Double Minute-2) is required to control cellular p53 activity and protein levels. Mdm2 null embryos die of p53-mediated growth arrest and apoptosis at the peri-implantation stage. Thus, the absolute requirement for Mdm2 in organogenesis is unknown. This study examined the role of Mdm2 i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086838/ https://ncbi.nlm.nih.gov/pubmed/21420949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2011.03.017 |
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