Ordered and Dynamic Assembly of Single Spliceosomes

The spliceosome is the complex macromolecular machine responsible for removing introns from precursors to mRNAs (pre-mRNAs). We combined yeast genetic engineering, chemical biology, and multi-wavelength fluoresence microscopy to follow assembly of single spliceosomes in real time in whole cell extra...

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Main Authors: Hoskins, Aaron A., Friedman, Larry J., Gallagher, Sarah S., Crawford, Daniel J., Anderson, Eric G., Wombacher, Richard, Ramirez, Nicholas, Cornish, Virginia W., Gelles, Jeff, Moore, Melissa J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086749/
https://ncbi.nlm.nih.gov/pubmed/21393538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198830
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