Single molecule analysis reveals reversible and irreversible steps during spliceosome activation

The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated...

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Bibliographic Details
Published in:eLife
Main Authors: Hoskins, Aaron A, Rodgers, Margaret L, Friedman, Larry J, Gelles, Jeff, Moore, Melissa J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922858/
https://ncbi.nlm.nih.gov/pubmed/27244240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14166
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