Alternative Spliceosome Assembly Pathways Revealed by Single Molecule Fluorescence Microscopy

Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered, with stable recruitment of U1 snRNP to the 5' splice site n...

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Autores principales: Shcherbakova, Inna, Hoskins, Aaron A., Friedman, Larry J., Serebrov, Victor, Corrêa, Ivan R., Xu, Ming-Qun, Gelles, Jeff, Moore, Melissa J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927372/
https://ncbi.nlm.nih.gov/pubmed/24075986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.026
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