PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availab...

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Main Authors: Bai, Péter, Canto, Carles, Oudart, Hughes, Brunyánszki, Attila, Cen, Yana, Thomas, Charles, Yamamoto, Hiroyasu, Huber, Aline, Kiss, Borbála, Houtkooper, Riekelt H., Schoonjans, Kristina, Schreiber, Valérie, Sauve, Anthony A., Murcia, Josiane Menissier-de, Auwerx, Johan
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086520/
https://ncbi.nlm.nih.gov/pubmed/21459330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.03.004
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