PARP-2 regulates SIRT1 expression and whole body energy expenditure

SIRT1 is a NAD(+)-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here we tested whether deletion of PARP-2, an alternative NAD(+) consuming enzyme, impacts on NAD(+) bioavailability and SIRT1 activity. Our results indicate that PARP-2...

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Detalhes bibliográficos
Main Authors: Bai, Péter, Canto, Carles, Brunyánszki, Attila, Huber, Aline, Szántó, Magdolna, Cen, Yana, Yamamoto, Hiroyasu, Houten, Sander M., Kiss, Borbala, Oudart, Hugues, Gergely, Pál, Menissier-de Murcia, Josiane, Schreiber, Valérie, Sauve, Anthony A., Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108571/
https://ncbi.nlm.nih.gov/pubmed/21459329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.03.013
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