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Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase.
The role of the enzyme poly(adenosine diphosphate-ribose) polymerase (PADPRP) in DNA repair at the level of the gene was investigated with human HeLa cells in which PADPRP antisense transcripts are inducible with dexamethasone. After such induction, the cellular content of PADPRP is reduced by 90%....
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1994
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC308509/ https://ncbi.nlm.nih.gov/pubmed/7984410 |
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