Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

In response to high levels of DNA damage, catalytic activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) triggers necrotic death because of rapid consumption of its substrate β-nicotinamide adenine dinucleotide and consequent depletion of ATP. We examined whether there are other conse...

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Détails bibliographiques
Auteurs principaux: Affar, El Bachir, Shah, Rashmi G., Dallaire, Annie-Karine, Castonguay, Vincent, Shah, Girish M.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC117546/
https://ncbi.nlm.nih.gov/pubmed/11756665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012460399
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