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Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage
In response to high levels of DNA damage, catalytic activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) triggers necrotic death because of rapid consumption of its substrate β-nicotinamide adenine dinucleotide and consequent depletion of ATP. We examined whether there are other conse...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117546/ https://ncbi.nlm.nih.gov/pubmed/11756665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012460399 |
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