Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage
In response to high levels of DNA damage, catalytic activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) triggers necrotic death because of rapid consumption of its substrate β-nicotinamide adenine dinucleotide and consequent depletion of ATP. We examined whether there are other conse...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
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| मुख्य लेखकों: | , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
2001
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756665/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012460399 |
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