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Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

In response to high levels of DNA damage, catalytic activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) triggers necrotic death because of rapid consumption of its substrate β-nicotinamide adenine dinucleotide and consequent depletion of ATP. We examined whether there are other conse...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Affar, El Bachir, Shah, Rashmi G., Dallaire, Annie-Karine, Castonguay, Vincent, Shah, Girish M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117546/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756665/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012460399
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