Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

In response to high levels of DNA damage, catalytic activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) triggers necrotic death because of rapid consumption of its substrate β-nicotinamide adenine dinucleotide and consequent depletion of ATP. We examined whether there are other conse...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Affar, El Bachir, Shah, Rashmi G., Dallaire, Annie-Karine, Castonguay, Vincent, Shah, Girish M.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756665/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012460399
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