Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage

Arsenic enhances skin tumor formation when combined with other carcinogens, including UV radiation (UVR). In this study we report that low micromolar concentrations of arsenite synergistically increases UVR-induced oxidative DNA damage in human keratinocytes as detected by 8-hydroxyl-2′-deoxyguanine...

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Detalhes bibliográficos
Main Authors: Ding, Wei, Liu, Wenlan, Cooper, Karen L., Qin, Xu-Jun, de Souza Bergo, Patrícia L., Hudson, Laurie G., Liu, Ke Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652344/
https://ncbi.nlm.nih.gov/pubmed/19056730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805566200
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