Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage

Arsenic enhances skin tumor formation when combined with other carcinogens, including UV radiation (UVR). In this study we report that low micromolar concentrations of arsenite synergistically increases UVR-induced oxidative DNA damage in human keratinocytes as detected by 8-hydroxyl-2′-deoxyguanine...

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Bibliografiske detaljer
Main Authors: Ding, Wei, Liu, Wenlan, Cooper, Karen L., Qin, Xu-Jun, de Souza Bergo, Patrícia L., Hudson, Laurie G., Liu, Ke Jian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652344/
https://ncbi.nlm.nih.gov/pubmed/19056730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805566200
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