Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage

Arsenic enhances skin tumor formation when combined with other carcinogens, including UV radiation (UVR). In this study we report that low micromolar concentrations of arsenite synergistically increases UVR-induced oxidative DNA damage in human keratinocytes as detected by 8-hydroxyl-2′-deoxyguanine...

Full description

Saved in:
Bibliographic Details
Main Authors: Ding, Wei, Liu, Wenlan, Cooper, Karen L., Qin, Xu-Jun, de Souza Bergo, Patrícia L., Hudson, Laurie G., Liu, Ke Jian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652344/
https://ncbi.nlm.nih.gov/pubmed/19056730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805566200
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items