Survey of Activated FLT3 Signaling in Leukemia

Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML remain unclear. To develop...

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Detalhes bibliográficos
Main Authors: Gu, Ting-lei, Nardone, Julie, Wang, Yi, Loriaux, Marc, Villén, Judit, Beausoleil, Sean, Tucker, Meghan, Kornhauser, Jon, Ren, Jianmin, MacNeill, Joan, Gygi, Steven P., Druker, Brian J., Heinrich, Michael C., Rush, John, Polakiewicz, Roberto D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084268/
https://ncbi.nlm.nih.gov/pubmed/21552520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019169
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