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Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis

Phosphopeptide identification and site determination are major challenges in biomedical MS. Both are affected by frequent and often overwhelming losses of phosphoric acid in ion trap CID fragmentation spectra. These losses are thought to translate into reduced intensities of sequence informative ion...

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Detalhes bibliográficos
Main Authors: Villén, Judit, Beausoleil, Sean A., Gygi, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745099/
https://ncbi.nlm.nih.gov/pubmed/18972524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200800283
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