Signaling networks assembled by oncogenic EGFR and c-Met

A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutations respond clinically to EGFR inhibitors (EGFRIs),...

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Bibliografski detalji
Glavni autori: Guo, Ailan, Villén, Judit, Kornhauser, Jon, Lee, Kimberly A., Stokes, Matthew P., Rikova, Klarisa, Possemato, Anthony, Nardone, Julie, Innocenti, Gregory, Wetzel, Randall, Wang, Yi, MacNeill, Joan, Mitchell, Jeffrey, Gygi, Steven P., Rush, John, Polakiewicz, Roberto D., Comb, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206598/
https://ncbi.nlm.nih.gov/pubmed/18180459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707270105
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