Signaling networks assembled by oncogenic EGFR and c-Met

A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutations respond clinically to EGFR inhibitors (EGFRIs),...

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Detalhes bibliográficos
Main Authors: Guo, Ailan, Villén, Judit, Kornhauser, Jon, Lee, Kimberly A., Stokes, Matthew P., Rikova, Klarisa, Possemato, Anthony, Nardone, Julie, Innocenti, Gregory, Wetzel, Randall, Wang, Yi, MacNeill, Joan, Mitchell, Jeffrey, Gygi, Steven P., Rush, John, Polakiewicz, Roberto D., Comb, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206598/
https://ncbi.nlm.nih.gov/pubmed/18180459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707270105
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