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ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism
Most type IB topoisomerases do not require ATP and Mg(2+) for activity. However, as shown previously for vaccinia topoisomerase I, we demonstrate that ATP stimulates the relaxation activity of the unusual heterodimeric type IB topoisomerase from Leishmania donovani (LdTOP1L/S) in the absence of Mg(2...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082896/ https://ncbi.nlm.nih.gov/pubmed/21186185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1284 |
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