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Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase.
We report the activities of HIV integrase protein on a novel DNA substrate, consisting of a pair of gapped duplex molecules. Integrase catalyzed an intermolecular disintegration reaction that requires positioning of a pair of the gapped duplexes in a configuration that resembles the intgration inter...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1994
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307927/ https://ncbi.nlm.nih.gov/pubmed/8152908 |
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