Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.

Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3' end pro...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hazuda, D J, Felock, P J, Hastings, J C, Pramanik, B, Wolfe, A L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.7005-7011.1997
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