HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Diketo acids such as L-731,988 are potent inhibitors of HIV-1 integrase that inhibit integration and viral replication in cells. These compounds exhibit the unique ability to inhibit the strand transfer activity of integrase in the absence of an effect on 3′ end processing. To understand the reasons...

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Main Authors: Espeseth, Amy S., Felock, Peter, Wolfe, Abigail, Witmer, Marc, Grobler, Jay, Anthony, Neville, Egbertson, Melissa, Melamed, Jeffrey Y., Young, Steve, Hamill, Terence, Cole, James L., Hazuda, Daria J.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17185/
https://ncbi.nlm.nih.gov/pubmed/11016953
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