HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Diketo acids such as L-731,988 are potent inhibitors of HIV-1 integrase that inhibit integration and viral replication in cells. These compounds exhibit the unique ability to inhibit the strand transfer activity of integrase in the absence of an effect on 3′ end processing. To understand the reasons...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Espeseth, Amy S., Felock, Peter, Wolfe, Abigail, Witmer, Marc, Grobler, Jay, Anthony, Neville, Egbertson, Melissa, Melamed, Jeffrey Y., Young, Steve, Hamill, Terence, Cole, James L., Hazuda, Daria J.
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 2000
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC17185/
https://ncbi.nlm.nih.gov/pubmed/11016953
תגים: הוספת תג
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