Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity
The N-terminal domain of HIV-1 integrase contains a pair of His and Cys residues (the HHCC motif) that are conserved among retroviral integrases. Although His and Cys residues are often involved in binding zinc, the HHCC motif does not correspond to any recognized class of zinc binding domain. We ha...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8942990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13659 |
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