Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

The N-terminal domain of HIV-1 integrase contains a pair of His and Cys residues (the HHCC motif) that are conserved among retroviral integrases. Although His and Cys residues are often involved in binding zinc, the HHCC motif does not correspond to any recognized class of zinc binding domain. We ha...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Zheng, Ronglan, Jenkins, Timothy M., Craigie, Robert
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1996
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8942990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13659
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