Structure-Activity Relationships in Nucleotide Oligomerization Domain-1 (Nod1)-Agonistic γ-Glutamyl-diaminopimelic Acid Derivatives

N-acyl-γ-glutamyl-diaminopimelic acid is a prototype ligand for Nod1. We report a detailed SAR of C(12)-γ-D-Glu-DAP. Analogues with glutaric or γ-aminobutyric acid replacing the glutamic acid show greatly attenuated Nod1-agonistic activity. Substitution of the meso-diaminopimelic (DAP) acid componen...

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Main Authors: Agnihotri, Geetanjali, Ukani, Rehman, Malladi, Subbalakshmi S., Warshakoon, Hemamali J., Balakrishna, Rajalakshmi, Wang, Xinkun, David, Sunil A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076632/
https://ncbi.nlm.nih.gov/pubmed/21299227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101535e
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