Structure-Activity Relationships in Toll-like Receptor-2 agonistic Diacylthioglycerol Lipopeptides

The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl residue. Lipopeptides derived from lipoproteins activate innate immune responses by engaging Toll-like receptor 2 (TLR2), and are highly immunostimulatory and yet without apparent toxicity in animal model...

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Autors principals: Wu, Wenyan, Li, Rongti, Malladi, Subbalakshmi S., Warshakoon, Hemamali J., Kimbrell, Matthew R., Amolins, Michael W., Ukani, Rehman, Datta, Apurba, David, Sunil A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859677/
https://ncbi.nlm.nih.gov/pubmed/20302301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901839g
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