Structure-Activity Relationships in Toll-like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides

Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-R-cysteinyl-S-serine (PAM(2)CS) compounds are potential vaccine adjuvants. In continuation of previously reported structure-activity relationships on this chemotype, we have determined that at least one ac...

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Main Authors: Agnihotri, Geetanjali, Crall, Breanna M., Lewis, Tyler C., Day, Timothy P., Balakrishna, Rajalakshmi, Warshakoon, Hemamali J., Malladi, Subbalakshmi S., David, Sunil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228886/
https://ncbi.nlm.nih.gov/pubmed/22007676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201071e
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