Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral replication is unclear. We report that HCV RNA replication and assembly of the viral replication complex require geranylgeranylation of one or...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Ye, Jin, Wang, Chunfu, Sumpter, Rhea, Brown, Michael S., Goldstein, Joseph L., Gale, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14668447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237238100
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