Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral replication is unclear. We report that HCV RNA replication and assembly of the viral replication complex require geranylgeranylation of one or...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Ye, Jin, Wang, Chunfu, Sumpter, Rhea, Brown, Michael S., Goldstein, Joseph L., Gale, Michael
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14668447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237238100
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