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PKR-mediated stress response enhances dengue and Zika virus replication

ABSTRACT The mechanisms by which flaviviruses use non-canonical translation to support their replication in host cells are largely unknown. Here, we investigated how the integrated stress response (ISR), which promotes translational arrest by eIF2ɑ phosphorylation (p-eIF2ɑ), regulates flavivirus rep...

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Autori principali: Taissa Ricciardi-Jorge, Edroaldo Lummertz da Rocha, Edgar Gonzalez-Kozlova, Gabriela Flavia Rodrigues-Luiz, Brian J. Ferguson, Trevor Sweeney, Nerea Irigoyen, Daniel Santos Mansur
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2023-10-01
Serie:mBio
Soggetti:
dengue virus
Zika virus
innate immunity
protein translation
PKR
Accesso online:https://journals.asm.org/doi/10.1128/mbio.00934-23
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