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Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral replication is unclear. We report that HCV RNA replication and assembly of the viral replication complex require geranylgeranylation of one or...

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Hlavní autoři: Ye, Jin, Wang, Chunfu, Sumpter, Rhea, Brown, Michael S., Goldstein, Joseph L., Gale, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC307659/
https://ncbi.nlm.nih.gov/pubmed/14668447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2237238100
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